Noncoding RNAs in Chromatin Organization and Transcription Regulation: An Epigenetic View
作者： Karthigeyan Dhanasekaran , Sujata Kumari , Chandrasekhar Kanduri
DOI: 10.1007/978-94-007-4525-4_15
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摘要: The Genome of a eukaryotic cell harbors genetic material in the form DNA which carries hereditary information encoded their bases. Nucleotide bases are transcribed into complimentary RNA further translated protein, performing defined set functions. central dogma life ensures sequential flow among these biopolymers. Noncoding RNAs (ncRNAs) serve as exceptions for this principle they do not code any protein. Nevertheless, major portion human transcriptome comprises noncoding RNAs. These vary size, well spatio-temporal distribution. ncRnAs functional and shown to be involved diverse cellular activities. Precise location expression ncRNA is essential homeostasis. Failures events ultimately results numerous disease conditions including cancer. present review lists out various classes ncRNAs with special emphasis on role chromatin organization transcription regulation.
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