Prevention of mammary carcinogenesis in C3H/OuJ mice by green tea and tamoxifen.

作者: Hiromitsu Jinno , Shigeru Imoto , Yuko Kitagawa , Michio Sakata , Tadashi Ikeda

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摘要: Background: Tamoxifen (TAM) is useful in the chemoprevention of breast cancer, and green tea catechins, including (-)-epigallocatechin gallate (EGCG), may have similar actions. In this study, we investigated their effects, alone or combination, on mammary carcinogenesis using cancer cells preneoplastic lesions inC3H/OuJ mice. Methods: Growth inhibitory effects EGCG TAM MCF-7 were evaluated with anchorage-independent colony forming assay. The tumor assessed vivo animals treated GTE drinking water (1%, 0.1%), a tamoxifen pellet (10 mg/ animal, subcutaneously inoculated) both agents combination (1%GTE + 10 mg TAM). number size tumors measured weekly during treatment. At 48 weeks age, mice sacrificed for examination hyperplastic alveolar nodules (HAN) argyrophilic nucleolar organizer regions (AgNOR). Results: growth assay, exhibited dose-dependent antiproliferative cells. formation incidences decreased GTE, TAM, GTE+TAM groups, particularly latter, which no developed. AgNOR counts also significantly lower 1%GTE+TAM compared 1%GTE group, suggesting an additional anticarcinogenic effect. Conclusion: These data suggest that individually potential cancer.

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