Multiple In Vitro Bioassay Approach in Sediment Toxicity Evaluation: Masan Bay, Korea
作者： Jee-Hyun Jung , Sang Hee Hong , Un Hyuk Yim , Sung Yong Ha , Won Joon Shim
DOI: 10.1007/S00128-012-0656-1
关键词:
摘要: Extracts of 21 sediment samples from Masan Bay, Korea, used in an earlier chemical measurement, were screened for their ability to induce estrogen, – and dioxin like gene expression using the E-Assay (+), DR-CALUX assay, respectively, inhibit acetylcholinesterase (AChE) activity vitro AChE assay. Biological impact industry-rich inner bay is higher than outer bay. DDTs (0.65), coplanar PCBs (0.77), HCHs (0.64), PAHs (0.61) APs (0.53) with good correlation E-assay (+) are seen as environmental estrogens. The highest induction response was again at station M12 15 which received sewage effluents. PCDD/DFs gave (0.75). Interestingly, treatment outlet showed activity. Among targeted chemicals (0.66), DDT (0.49) correlated well bioassay. Spearman rank on analytical biochemical results affirmed ‘hot spots’ point sources (e.g., industrial outfall) suspected toxicants. Significant correlations between organo chlorine pesticides, PCBs, dioxins alkylphenols biological effects observed.
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