Current Mechanistic Understanding of Cobalt-Catalyzed C–H Functionalization

摘要: Abstract Arguably, one of the biggest advancements in synthetic chemistry over recent decades, has been development Pd cross-coupling procedures. The application Pd-catalyzed reactions is nowadays a powerful and widely applied tool during preparation wide range pharmaceuticals, agrochemicals, intermediates. Recently, use cheaper, more abundant, less toxic first-row transition metals to replace expensive started attract significant attention. While at same time, direct C–H functionalization necessity halogenated precursors also topic interest order develop cleaner environmentally friendly In this context, cobalt-catalyzed provided platform address these desires. mechanistic diversity newly developed protocols using cobalt quite extraordinary varied than when applying corresponding second third row analogs. This overview seeks exemplify highlight potential as basis for protocols, focusing on mechanisms available arising from rich redox metal.