Fluorodeoxyglucose rate constants, lumped constant, and glucose metabolic rate in rabbit heart.

摘要: The isolated arterial perfused rabbit interventricular septum was used to measure myocardial metabolic rate for glucose (MMRGlc) and constants lumped constant (LC) the analogue (/sup 18/F)fluorodeoxyglucose (FDG) using a tracer kinetic model. FDG delivered by infusion during coincidence counting of tissue /sup 18/F radioactivity. MMRGlc measured Fick method. Control septa were paced at 72 beats/min 1.5 ml/min with oxygenated perfusate containing 5.6 mM 5 mU/ml insulin. following conditions tested: 3.0 4.5 ml/min; insulin increased 25 mU/ml; omitted; 2.8 11.2 glucose; 144 96 paired stimuli/min; anoxia. Under all studied phosphorylation (hexokinase) reaction limiting relative transport. Compared control conditions, significantly as well in With glucose, that should increase flux into without increasing demand, decreased significantly. stimuli/min, anoxia insulin, significant hydrolysis 6-phosphate observed suggests is also an importantmore » mechanism regulating MMRGlc. Increased transport flow rates, beats/min. LC not different from 11 14 studied. Therefore, under most average can be calculate estimates.« less