Targeting 5-lipoxygenase-activating protein in asthma and chronic obstructive pulmonary disease

摘要: Introduction: In asthma and chronic obstructive pulmonary disease (COPD), there is an unmet therapeutic need for the anti-inflammatory therapies, identification of targets potent corresponding therapies necessary. Although inhaled corticosteroids leukotriene modifiers are most effective in they still not always capable appropriately controlling disease. COPD, gap even larger because other beneficial all subsets.Areas covered: The role 5-lipoxygenase-activating protein (FLAP) generating proinflammatory molecules such as leukotrienes discussed, highlighting, particular, its potential a target COPD. preclinical data on FLAP inhibitors discussed. clinical investigated so far these diseases analyzed.Expert opinion: have emerged during past decade prom...