Small RNA drugs for prion disease: a new frontier

摘要: Introduction: Prion diseases, also known as transmissible spongiform encephalopathies, are a group of neurodegenerative diseases that invariably incurable. In fact, intense laboratory and clinical research have failed to discover effective treatments, date, which delay the onset or progression any conditions, including those caused by infectious prions. It has become clear profound changes in brains patients evident long before signs it is at this stage disease reversible presents ‘druggable' targets. However, beginning uncover molecular underpinnings involved early stages pathogenesis. Targeting key genes pathways using short non-coding RNA new avenue exploratory for treatment prion holds much promise future. Areas covered: This article reviews novel approach RNA-based drugs therapeutic opportunity disease. Furthermore, ...