Islet morphogenesis and stem cell markers in rat pancreas.

摘要: During embryonic development, and possibly also later in life, pancreatic islets of Langerhans originate from differentiating epithelial stem cells. These cells are situated the ducts but otherwise poorly characterized. We found by immunohistochemical staining that protodifferentiated rat embryos Day 13-Day 15 express cytoskeletal protein keratin 20, similar to mature duct epithelium. period islet morphogenesis, which occurs between 17 birth, large aggregates K20-positive were formed, gradually differentiated into endocrine This morphogenic mechanism has not been described thus far we did observe it postnatal rats. fetal formation, transient expression vimentin was noted intermediate filament is observed after birth. The proto-oncogene product bcl-2, a putative stem...