Exploration of Survival Traits, Probiotic Determinants, Host Interactions, and Functional Evolution of Bifidobacterial Genomes Using Comparative Genomics.

摘要: Members of the genus Bifidobacterium are found in a wide-range habitats and used as important probiotics. Thus, exploration their functional traits at level is utmost significance. Besides, this has been demonstrated to exhibit an open pan-genome based on limited number genomes earlier studies. However, crucial factor for calculations. We have analyzed comparatively larger dataset 215 members belonging different habitats, which revealed nature. The 56 probiotic human-gut strains genus, was also be open. accessory- unique-components were under operation Darwinian selection pressure. Further, genome-size variation predicted attributed abundance certain functions carried by genomic islands, facilitated insertion elements prophages. In silico host-microbe interaction analyses core-genome significant factors niche-specific adaptations traits. core survival include stress tolerance, biofilm formation, nutrient transport, Sec-secretion system, whereas imparted involved carbohydrate- protein-metabolism host-immunomodulations.