Histone methyltransferase DOT1L controls state-specific identity during B cell differentiation
作者： Muhammad Assad Aslam , Mir Farshid Alemdehy , Eliza Mari Kwesi-Maliepaard , Marieta Caganova , Iris N. Pardieck
DOI: 10.1101/826370
关键词:
摘要: Development of naive peripheral B cells into terminally differentiated plasma is a highly controlled process guided by epigenetic mechanisms. Here we identified central role for the histone H3K79 methyltransferase DOT1L in controlling cell development. Upon deletion Dot1L early B-cell lineage, and activated prematurely acquired features failed to establish germinal centers (GC) normal humoral immune responses vivo. Transcriptome analyses revealed that promotes expression oncogenic, pro-proliferative pro-GC transcription factors. Simultaneously, indirectly repression anti-proliferative targets Polycomb Repressor Complex 2. Our findings show fine tunes transcriptional landscape cells. In doing so it establishes critical barrier warranting naivety prohibiting premature differentiation towards
sci-hub.st 参考文章(90)
Yan Bao, Xuetao Cao, Epigenetic Control of B Cell Development and B-Cell-Related Immune Disorders Clinical Reviews in Allergy & Immunology. ,vol. 50, pp. 301- 311 ,(2016) , 10.1007/S12016-015-8494-7
Floor Frederiks, Manuel Tzouros, Gideon Oudgenoeg, Tibor van Welsem, Maarten Fornerod, Jeroen Krijgsveld, Fred van Leeuwen, Nonprocessive methylation by Dot1 leads to functional redundancy of histone H3K79 methylation states Nature Structural & Molecular Biology. ,vol. 15, pp. 550- 557 ,(2008) , 10.1038/NSMB.1432
Yi Feng, Yanping Yang, Manoela M. Ortega, Jessica N. Copeland, Mingcai Zhang, Jennifer B. Jacob, Timothy A. Fields, Jay L. Vivian, Patrick E. Fields, Early mammalian erythropoiesis requires the Dot1L methyltransferase. Blood. ,vol. 116, pp. 4483- 4491 ,(2010) , 10.1182/BLOOD-2010-03-276501
Marta Radman-Livaja, Kitty F. Verzijlbergen, Assaf Weiner, Tibor van Welsem, Nir Friedman, Oliver J. Rando, Fred van Leeuwen, Patterns and mechanisms of ancestral histone protein inheritance in budding yeast. PLOS Biology. ,vol. 9, ,(2011) , 10.1371/JOURNAL.PBIO.1001075
E. Hobeika, S. Thiemann, B. Storch, H. Jumaa, P. J. Nielsen, R. Pelanda, M. Reth, Testing gene function early in the B cell lineage in mb1-cre mice Proceedings of the National Academy of Sciences of the United States of America. ,vol. 103, pp. 13789- 13794 ,(2006) , 10.1073/PNAS.0605944103
Wei Shi, Yang Liao, Simon N Willis, Nadine Taubenheim, Michael Inouye, David M Tarlinton, Gordon K Smyth, Philip D Hodgkin, Stephen L Nutt, Lynn M Corcoran, Transcriptional profiling of mouse B cell terminal differentiation defines a signature for antibody-secreting plasma cells Nature Immunology. ,vol. 16, pp. 663- 673 ,(2015) , 10.1038/NI.3154
Zimu Deng, Haifeng Liu, Xiaolong Liu, RAG1-mediated ubiquitylation of histone H3 is required for chromosomal V(D)J recombination Cell Research. ,vol. 25, pp. 181- 192 ,(2015) , 10.1038/CR.2015.1
C M McLean, I D Karemaker, F van Leeuwen, The emerging roles of DOT1L in leukemia and normal development Leukemia. ,vol. 28, pp. 2131- 2138 ,(2014) , 10.1038/LEU.2014.169
Akihiko Muto, Kyoko Ochiai, Yoshitaka Kimura, Ari Itoh-Nakadai, Kathryn L Calame, Dai Ikebe, Satoshi Tashiro, Kazuhiko Igarashi, Bach2 represses plasma cell gene regulatory network in B cells to promote antibody class switch The EMBO Journal. ,vol. 29, pp. 4048- 4061 ,(2010) , 10.1038/EMBOJ.2010.257
María J. Barrero, Stephanie Boué, Juan Carlos Izpisúa Belmonte, Epigenetic Mechanisms that Regulate Cell Identity Cell Stem Cell. ,vol. 7, pp. 565- 570 ,(2010) , 10.1016/J.STEM.2010.10.009