Temperature dependence of the asymmetric induction in the PtCl(SnCl3)[(−)-(2S,4S)-2,4-bis(diphenylphosphino)pentane]-catalyzed enantioselective hydroformylation reaction

摘要: Abstract Asymmetric hydroformylation of some prochiral olefins has been shown to be catalyzed by a new (preformed) PtCl(SnCl 3 )[( S , )-BDPP] (( )-BDPP = (−)-(2 ,4 )-2,4-bis(diphenylphosphino)pentane) catalyst. Vinylidene carboxylic esters are hydroformylated regioselectively but with rather moderate enantioselectivity. In styrene the linear non chiral regioisomer 3-phenylpropanal is main product, enantioselective formation 2-phenylpropanal strongly influenced reaction temperature, The -enantiomer predominate at lower and R -species higher temperatures. Appropriate choices partial pressure CO H 2 led relatively high (76.5%) enantiomeric excess.