Recent developments on ketolides and macrolides

摘要: Recent semi-synthetic studies of erythromycin A culminated in the discovery two ketolide drug candidates, HMR-3647 and ABT-773, for treatment community-acquired bacterial infections caused by both macrolide- beta-lactam-susceptible -resistant S. pneumoniae, gram negative bacteria, intracellular atypical pathogens. The ketolides has rekindled interest macrolides, recent efforts have also led to a novel class 4''-carbamates with activity against macrolide-resistant organisms. This review is an account developments on macrolides terms chemistry antibacterial activity.