Aggregated aluminium exposure: risk assessment for the general population.

摘要: Aluminium is one of the most abundant elements in earth’s crust and its manifold uses result an exposure population from many sources. Developmental toxicity, effects on urinary tract neurotoxicity are known aluminium compounds. Here, we assessed health risks resulting total consumer towards various compounds, including contributions foodstuffs, food additives, contact materials (FCM), cosmetic products. For estimation contents foodstuff, data German “Pilot-Total-Diet-Study” were used, which was conducted as part European TDS-Exposure project. These combined with consumption National Consumption Survey II to yield via for adults. It found that average weekly intake amounts approx. 50% tolerable (TWI) 1 mg/kg body weight (bw)/week, derived by Food Safety Authority (EFSA). children, French “Infant Total Diet Study” “Second used estimate food. As a result, TWI can be exhausted or slightly exceeded—particularly infants who not exclusively breastfed young children relying specially adapted diets (e.g. soy-based, lactose free, hypoallergenic). When taking into account overall foods, products (cosmetics), pharmaceuticals FCM uncoated aluminium, significant exceedance EFSA-derived even PTWI 2 mg/kg bw/week, Joint FAO/WHO Expert Committee Additives, may occur. Specifically, high levels adolescents aged 11–14 years. Although collected special regard population, it also representative comparable international consumers. From toxicological point view, regular lifetime (TWI/PTWI) undesirable, since this results increased risk impairments. Consequently, recommendations how reduce given.