Stress Induced by Recombinant Protein Production in Escherichia coli

摘要: Strong production of recombinant proteins interferes with cellular processes in many ways. Drainage precursors and energy urges the cell to readjust metabolic fluxes enzyme composition, stress responses are induced, hence activity is shifted from growth reorganisation biomass. This may result inhibition or low level product accumulation. The extent bacterial response determined by specific properties protein, rates transcription translation. Taking into account capacities host for protein processing physiological adaptation, schemes can be developed that enhance volumetric productivity sustainability process.