PEDOT:gelatin composites mediate brain endothelial cell adhesion

摘要: Conducting polymers (CPs) are increasingly being used to interface with cells for applications in both bioelectronics and tissue engineering. To facilitate this interaction, need adhere grow on the CP surface. Extracellular matrix components usually necessary support or enhance cell attachment growth polymer substrates. Here we show preparation of PEDOT(TOS):gelatin composites as a new biocompatible substrate use Gelatin, derivative extracellular protein collagen, was incorporated into poly(3,4 ethylenedioxythiophene)-tosylate (PEDOT(TOS)) films via vapour phase polymerisation (VPP) without changing electrochemical properties CP. Further, gelatin, PEDOT(TOS) film, found specifically bovine brain capillary endothelial adhesion growth, indicating that functionality biomolecule maintained. The biocompatibility composite demonstrated significant future potential biocomposites type promoting electrically active materials