Considerable exposure to the endocrine disrupting chemicals phthalates and bisphenol-A in intensive care unit (ICU) patients.

摘要: Critical care medicine has largely benefited from plastic-containing medical devices. However, bisphenol-A (BPA) and phthalates present in the plastics can leach such We hypothesized that intensive unit (ICU) patients are exposed to BPA through (plastic) Serum (n = 118) urine (n= 102) samples of adult ICU 35) were analyzed for total phthalate metabolites (PMs). Our results showed continuously phthalates, as di(2-ethylhexyl)phthalate (DEHP), well BPA, albeit a lesser extent. This exposure resulted detectable high serum urinary levels almost every patient at studied time point. Moreover, these significantly higher than controls or compared referenced literature. The chronology was demonstrated: pre-operative DEHP often below detection limit. Plastic-containing devices main source exposure: post-operative on hemofiltration, extracorporeal membrane oxygenation both 100-or 1000-fold general population reported some highest ever humans; biologically highly relevant concentrations ≥ 10-50 μM. Despite tightening regulations, appear be still (some) Because safety is concern ICU, further research into (possibly toxic clinical) effects chemicals released imperiously necessary.