A clinical model for quality of life assessment in cancer patients receiving chemotherapy.
作者： M.C. Klee , M.T. King , D. Machin , H.H. Hansen
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摘要: Summary Background The pattern of symptoms experienced by cancer patients during chemotherapy is very complex. Consequently, quality life (QOL) assessment has to be carefully planned capture clinically relevant changes. Patients and methods A clinical model changes in symptomatic metastatic several courses been developed. differentiates cancer-related symptoms, acute side-effects, chronic side-effects not related cancer. was used predict each these four symptom groups. Three time points were selected (post-cycle 2, pre-cycle 3, post-cycle 5) an appropriate window around point set. predictions swere tested empirically with 56 advanced ovarian who completed the EORTC QLQ-C30 plus disease specific items a six-cycle course chemotherapy. Results observed sample accordance predicted model. from did complete questionnaire within specified windows tended dilute findings group did. Conclusions useful planning QOL assessments order effects. Such models also facilitate interpretation studies, particularly when cyclic short-term effects are overlaid on as case for
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sci-hub.se 参考文章(21)
J Pater, D Osoba, B Zee, W Lofters, M Gore, E Dempsey, M Palmer, C Chin, Effects of altering the time of administration and the time frame of quality of life assessments in clinical trials: an example using the EORTC QLQ-C30 in a large anti-emetic trial. Quality of Life Research. ,vol. 7, pp. 273- 278 ,(1998) , 10.1023/A:1024954518241
M. Klee, Quality of life of Danish women: population-based norms of the EORTC QLQ-C30. Quality of Life Research. ,vol. 6, pp. 27- 34 ,(1997) , 10.1023/A:1026461310761
D. Crabeels, Darius Razavi, P. Fausler, S Ahmedzai, U. Frick, Stein Kaasa, S Schraub, Neil Aaronson, D Osoba, H Flechtner, Monika Bullinger, M Sullivan, J. Estape, F Takeda, M. Mastilica, A Filiberti, M Klee, C. Hurny, The EORTC core quality of life questionnaire: interim results of an international field study CRC Press Inc. pp. 185- 203 ,(1991)
J P Simons, N K Aaronson, J F Vansteenkiste, G P ten Velde, M J Muller, B M Drenth, F L Erdkamp, E G Cobben, E J Schoon, J B Smeets, H C Schouten, M Demedts, H F Hillen, G H Blijham, E F Wouters, Effects of medroxyprogesterone acetate on appetite, weight, and quality of life in advanced-stage non-hormone-sensitive cancer: a placebo-controlled multicenter study. Journal of Clinical Oncology. ,vol. 14, pp. 1077- 1084 ,(1996) , 10.1200/JCO.1996.14.4.1077
K Ekstrom, K Hoffman, T Linne, B Eriksson, B Glimelius, Single-dose etoposide in advanced pancreatic and biliary cancer, a phase II study. Oncology Reports. ,vol. 5, pp. 931- 935 ,(1998) , 10.3892/OR.5.4.931
D. Osoba, B. Zee, J. Pater, D. Warr, L. Kaizer, J. Latreille, Psychometric properties and responsiveness of the EORTC Quality of Life Questionnaire (QLQ-C30) in patients with breast, ovarian and lung cancer Quality of Life Research. ,vol. 3, pp. 353- 364 ,(1994) , 10.1007/BF00451727
P.M. Fayers, P. Hopwood, A. Harvey, D.J. Girling, D. Machin, R. Stephens, Quality of life assessment in clinical trials—guidelines and a checklist for protocol writers: the U.K. Medical Research Council experience European Journal of Cancer. ,vol. 33, pp. 20- 28 ,(1997) , 10.1016/S0959-8049(96)00412-1
Eva Hammerlid, Claes Mercke, Marianne Sullivan, Thomas Westin, A Prospective Quality of Life Study of Patients With Laryngeal Carcinoma by Tumor Stage and Different Radiation Therapy Schedules Laryngoscope. ,vol. 108, pp. 747- 759 ,(1998) , 10.1097/00005537-199805000-00023
P.J. Allison, D. Locker, J.S. Feine, Quality of life: a dynamic construct. Social Science & Medicine. ,vol. 45, pp. 221- 230 ,(1997) , 10.1016/S0277-9536(96)00339-5
D. Osoba, Benny Zee, David Warr, Jean Latreille, Leonard Kaizer, Joseph Pater, Effect of postchemotherapy nausea and vomiting on health-related quality of life Supportive Care in Cancer. ,vol. 5, pp. 307- 313 ,(1997) , 10.1007/S005200050078