Inhibition and reversal of nickel-induced transformation by the histone deacetylase inhibitor trichostatin A
作者： Qunwei Zhang , Konstantin Salnikow , Thomas Kluz , Lung Chi Chen , Wei Cheng Su
DOI: 10.1016/S0041-008X(03)00280-1
关键词:
摘要: The carcinogenic process initiated by nongenotoxic carcinogens involves modulation of gene expression. Nickel compounds have low mutagenic activity, but are highly carcinogenic. In vitro both mouse and human cells can be efficiently transformed soluble insoluble nickel to anchorage-independent growth. Because previous studies shown that silence genes inhibiting histone acetylation enhancing DNA methylation, we investigated the effect on cell transformation. exposure nickel-transformed deacetylase inhibitor trichostatin A (TSA) resulted in appearance significant number revertants measured their inability grow soft agar. Using Affymetrix GeneChip found level expression a was changed (suppressed or upregulated) clones returned normal obtained following TSA treatment. Moreover, treatment with inhibited ability transform PW Treatment also HOS cells, although lesser extent. contrast, not able revert established cancer lines as readily cells. These data indicated is important for nickel-induced
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