Major histocompatibility complex genes and locus organization in the Komodo dragon (Varanus komodoensis).

摘要: We performed a meta-analysis of the newly assembled Komodo dragon (Varanus komodoensis) genome to characterize major histocompatibility complex (MHC) species. The MHC gene clusters are dense, complex, and contain counterparts many genes human MHC. Our analysis identified 20 contigs encompassing ~ 6.9 Mbp sequence with 223 annotated which predicted orthologs These range in size from 13.2 kb 21.5 Mbp, an average one per 30 kb, thought occur on at least two chromosomes. Eight contigs, each > 100 kb, could be aligned based content, these represent found recognized mammalian subregions. shares organizational features other non-mammalian taxa. Multiple class Iα IIβ indicated, linkage between classical I immunoproteasome framework associated III subregion. findings supported both assemblies provide new insight into organization unique squamate reptiles.