Small-volume electrochemical detector for microcolumn liquid chromatography

作者: Y. Hirata , P.T. Lin , M. Novotný , R.M. Wightman

DOI: 10.1016/S0378-4347(00)81131-7

关键词:

摘要: Abstract A submicroliter electrochemical detector for liquid chromatography has been designed, using pressure-annealed pyrolytic graphite technology. The analytical performance of this was studied in connection with a reversed-phase packed microcapillary column at very low flow-rates. Although the miniaturized version is less sensitive, direct analysis number urinary metabolites 0.1–1.0 μl samples feasible.

参考文章(16)
F.A. Posey, R.E. Meyer, Chronopotentiometry and voltammetry of the AgAgCl electrode in flowing streams. Journal of Electroanalytical Chemistry. ,vol. 30, pp. 359- 373 ,(1971) , 10.1016/0368-1874(71)87020-X
D. Ishii, K. Asai, K. Hibi, T. Jonokuchi, M. Nagaya, A study of micro-high-performance liquid chromatography Journal of Chromatography A. ,vol. 144, pp. 157- 168 ,(1977) , 10.1016/S0021-9673(00)99351-8
T. Tsuda, K. Hibi, T. Nakanishi, T. Takeuchi, D. Ishii, Studies of open-tubular micro-capillary liquid chromatography Journal of Chromatography A. ,vol. 158, pp. 227- 232 ,(1978) , 10.1016/S0021-9673(00)89969-0
Stephen G Weber, William C Purdy, The behaviour of an electrochemical detector used in liquid chromatography and continuous flow voltammetry Analytica Chimica Acta. ,vol. 100, pp. 531- 544 ,(1978) , 10.1016/S0003-2670(01)93347-1
R.P.W. Scott, P. Kucera, The exclusion properties of some commercially available silica gels Journal of Chromatography A. ,vol. 125, pp. 251- 263 ,(1976) , 10.1016/S0021-9673(00)93823-8
Takao. Tsuda, Milos. Novotny, Packed microcapillary columns in high performance liquid chromatography Analytical Chemistry. ,vol. 50, pp. 271- 275 ,(1978) , 10.1021/AC50024A026
Ronald E. Shoup, Peter T. Kissinger, A Versatile Thin-Layer Detector Cell for High Performance Liquid Chromatography Instrumentation Science & Technology. ,vol. 7, pp. 171- 177 ,(1976) , 10.1080/10739147608543425
Yukio Hirata, Milos Novotny, Techniques of capillary liquid chromatography Journal of Chromatography A. ,vol. 186, pp. 521- 528 ,(1979) , 10.1016/S0021-9673(00)95272-5