Advances in the use of cell penetrating peptides for respiratory drug delivery.

摘要: Introduction: Respiratory diseases are leading causes of death in the world, still inhalation therapies largest fail drug development. There is an evident need to develop new therapies. Biomolecules represent apotential therapeutic agent this regard, however their translation clinic hindered by lack tools efficiently deliver molecules. Cell penetrating peptides (CPPs) have arisen as strategy for intracellular delivery that could theoretically enable therapies.Areas covered: In review, use CPPs astrategy different molecules (cargoes) treat lung-relateddiseases will be focus. Abrief description these and innovative methods designing presented. The cargoes (proteins, peptides, poorly soluble drugs nucleic acids) using discussed, focusing on benefits respiratory like inflammatory disorders, cystic fibrosis lung cancer.Expert opinion: advantages biomolecules lungs evident. This field has advanced past few years toward targeted delivery, although further studies needed fully understand its potential limitations vitro vivo.