Applications of nuclear magnetic resonance spectroscopy for the understanding of enantiomer separation mechanisms in capillary electrophoresis.

摘要: Abstract This review deals with the applications of nuclear magnetic resonance (NMR) spectroscopy to understand mechanisms chiral separation in capillary electrophoresis (CE). It is accepted that changes observed process, including reversal enantiomer migration order (EMO), can be caused by subtle modifications molecular recognition between and selector. These may imply minor structural differences those selector-selectand complexes arise from above mentioned interactions. Therefore, it mandatory fine intermolecular interactions analytes selectors. In other words, necessary know detail structures formed (selectand) Any these arising either should detected, so enantiomeric bias process could explained. As nature interactions, have been extensively reviewed, not intended discussed here. contemplate ionic, ion-dipole dipole–dipole hydrogen bonding, van der Waals forces, π − π stacking, steric hydrophobic The main subject this describe how NMR helps gain insight into non-covalent selector selectand lead CE. Examples which diastereomeric species are created covalent (irreversible) derivatization will considered structured upon different classes selectors employed CE, has made substantial contributions rationalize enantioseparations. Cases techniques complement spectroscopic data also mentioned.