Metabolic and immune system cross-talk in human adipose tissue

摘要: The overall aim of the work presented in this thesis was to further characterise aspects metabolic and immune system cross-talk human subcutaneous adipose tissue, with a particular emphasis on potential role T-lymphocytes tissue dysfunction insulin resistance. Chapter 3 characterised macrophage T-lymphocyte populations residing from lean through class I obese men. This demonstrated that display increased activation adiposity compensatory mechanisms may be present help counteract inflammation. In 4, same participants were exposed meal-based stimulus order examine postprandial inflammatory responses blood tissue. Despite glucose obesity, there no differences cytokine gene expression suggests limit or dampen output after feeding individuals modestly adiposity. 5 examined changes 50 % calorie restriction for days, resulting reduced serum leptin which temporally associated reduction activation. however, expression/secretion not neither resident activation, indicating local tissue-specific cells caloric restriction. 6 between either normal impaired tolerance, their respective 10 days diet activity modification. Overall, highlights key properties increasing levels resistance together times feeding, severe lowering activity.