Serum modulation of neutrophil response to Porphyromonas gingivalis LPS in periodontal disease.

摘要: Rapidly progressive periodontitis is a form of early onset characterised by severe gingival inflammation and rapid bone loss. Release lipopolysaccharide (LPS) from the outer membrane Gram negative bacteria initiates various biological activities including complement activation, cytotoxicity, resorption. Serum rapidly patients has been reported to enhance superoxide response normal neutrophils purified Porphyromonas gingivalis, compared control serum. The purpose this study was identify factor in serum which responsible for enhancement activity. Candidate molecules were considered be binding protein or antibody lipopolysaccharide. Lipopolysaccharide quantified ELISA, sera found contain two three fold more than sera. Removal either adsorption an anti protein-sepharose affinity column removed priming activity neutrophils. Addition exogenous enhanced dose dependent manner. These results suggest that may generation, result tissue damage these patients.