Design, synthesis and biological evaluation of paralleled Aza resveratrol-chalcone compounds as potential anti-inflammatory agents for the treatment of acute lung injury.
作者： Wenbo Chen , Xiangting Ge , Fengli Xu , Yali Zhang , Zhiguo Liu
DOI: 10.1016/J.BMCL.2015.05.030
关键词:
摘要: Acute lung injury (ALI) is a major cause of acute respiratory failure in critically-ill patients. It has been reported that both resveratrol and chalcone derivatives could ameliorate induced by inflammation. A series paralleled Aza resveratrol–chalcone compounds (5a–5m, 6a–6i) were designed, synthesized screened for anti-inflammatory activity. majority showed potent inhibition on the IL-6 TNF-α expression-stimulated LPS macrophages, which compound 6b most analog LPS-induced release dose-dependent manner. Moreover, exhibited protection against vivo. These results offer further insight into use treatment inflammatory diseases, as lead development anti-ALI agents.
sci-hub.se 参考文章(19)
Dominique Delmas, Virginie Aires, Emeric Limagne, Patrick Dutartre, Frédéric Mazué, François Ghiringhelli, Norbert Latruffe, Transport, stability, and biological activity of resveratrol. Annals of the New York Academy of Sciences. ,vol. 1215, pp. 48- 59 ,(2011) , 10.1111/J.1749-6632.2010.05871.X
Yong Pan, Yi Huang, Zhe Wang, Qilu Fang, Yusheng Sun, Chao Tong, Kesong Peng, Yangwei Wang, Lining Miao, Lu Cai, Yunjie Zhao, Guang Liang, None, Inhibition of MAPK‐mediated ACE expression by compound C66 prevents STZ‐induced diabetic nephropathy Journal of Cellular and Molecular Medicine. ,vol. 18, pp. 231- 241 ,(2014) , 10.1111/JCMM.12175
Mogens Larsen, Hasse Kromann, Arsalan Kharazmi, Simon Feldbæk Nielsen, Conformationally restricted anti-plasmodial chalcones Bioorganic & Medicinal Chemistry Letters. ,vol. 15, pp. 4858- 4861 ,(2005) , 10.1016/J.BMCL.2005.07.012
Piyush K. Agarwal, Natalia Sadetsky, Badrinath R. Konety, Martin I. Resnick, Peter R. Carroll, , Treatment failure after primary and salvage therapy for prostate cancer: likelihood, patterns of care, and outcomes. Cancer. ,vol. 112, pp. 307- 314 ,(2008) , 10.1002/CNCR.23161
Richard B Goodman, Jérôme Pugin, Janet S Lee, Michael A Matthay, Cytokine-mediated inflammation in acute lung injury. Cytokine & Growth Factor Reviews. ,vol. 14, pp. 523- 535 ,(2003) , 10.1016/S1359-6101(03)00059-5
Mei Liu, Prapon Wilairat, Mei-Lin Go, Antimalarial Alkoxylated and Hydroxylated Chalones: Structure−Activity Relationship Analysis Journal of Medicinal Chemistry. ,vol. 44, pp. 4443- 4452 ,(2001) , 10.1021/JM0101747
QIANG XIE, WEN-WEN SHEN, JIAN ZHONG, CHENG HUANG, LEI ZHANG, JUN LI, Lipopolysaccharide/adenosine triphosphate induces IL‑1β and IL-18 secretion through the NLRP3 inflammasome in RAW264.7 murine macrophage cells International Journal of Molecular Medicine. ,vol. 34, pp. 341- 349 ,(2014) , 10.3892/IJMM.2014.1755
James W. Collins, Kristie M. Keeney, Valerie F. Crepin, Vijay A. K. Rathinam, Katherine A. Fitzgerald, B. Brett Finlay, Gad Frankel, Citrobacter rodentium: infection, inflammation and the microbiota Nature Reviews Microbiology. ,vol. 12, pp. 612- 623 ,(2014) , 10.1038/NRMICRO3315
Ratchanok Pingaew, Amporn Saekee, Prasit Mandi, Chanin Nantasenamat, Supaluk Prachayasittikul, Somsak Ruchirawat, Virapong Prachayasittikul, Synthesis, biological evaluation and molecular docking of novel chalcone-coumarin hybrids as anticancer and antimalarial agents. European Journal of Medicinal Chemistry. ,vol. 85, pp. 65- 76 ,(2014) , 10.1016/J.EJMECH.2014.07.087
Shigeo Hayashi, Naomi Ueno, Akio Murase, Yoko Nakagawa, Junji Takada, Novel acid-type cyclooxygenase-2 inhibitors: Design, synthesis, and structure–activity relationship for anti-inflammatory drug European Journal of Medicinal Chemistry. ,vol. 50, pp. 179- 195 ,(2012) , 10.1016/J.EJMECH.2012.01.053