Resistin, Adiponectin, and Risk of Heart Failure

摘要: Objectives We tested the association of adipokines resistin and adiponectin with incident heart failure. Background Abnormal concentrations may partially explain between obesity Methods related circulating adipokine to incidence failure in 2,739 participants Framingham Offspring Study. Results During 6 years follow-up, 58 developed new-onset In proportional hazards models (adjusting for age, sex, blood pressure, antihypertensive treatment, diabetes, smoking, total/high-density lipoprotein cholesterol ratio, prevalent coronary disease, valvular left ventricular hypertrophy, estimated glomerular filtration rate) using lowest third distribution as referent, hazard ratios middle top thirds were 2.89 (95% confidence interval [CI]: 1.05 7.92) 4.01 CI: 1.52 10.57), respectively (p = 0.004 trend). Additional adjustment body mass index, insulin resistance (measured homeostasis model), C-reactive protein, B-type natriuretic peptide did not substantively weaken this (multivariable [HRs]: 2.62 3.74, p 0.007). maximally adjusted model, each SD increment (7.45 ng/ml) was associated a 26% increase risk 1% 60%). Concentrations HRs: 0.87 0.97, 0.9). Conclusions Increased failure, even after accounting obesity, measures inflammation. The findings suggest role human disease novel pathway