Hereditary carcinoma of the ovary and associated cancers: a study of two families.

摘要: Increasing attention has been given to host factors in the etiology of ovarian carcinoma. Case/control studies have shown a significant excess this disease among primary relatives cancer affected. Pedigree demonstrated its occurrence on site-specific basis, association with carcinoma breast (breast/ovarian syndrome), and other hereditary disorders. The complexity heterogeneity clearly warrants more intensive family studies. We described genetic clinicopathologic nuances two extended cancer-prone families. absence premonitory physical stigmata and/or biomarkers which signify genotype compels physician employ best posits from pedigree identify those patients who are at inordinately high risk for syndrome-associated so that surveillance strategies can be focused. Because limitations current early detection carcinoma, clinician's responsibility includes identification counseling candidates prophylactic oophorectomy.