Preoperative chlorhexidine reduces the incidence of surgical site infections in total knee and hip arthroplasty: A systematic review and meta-analysis

摘要: Abstract Objective This meta-analysis aims to assess the incidences of surgical site infection patients who applied preadmission chlorhexidine skin preparation, versus those traditional preparation before undergoing total knee and hip arthroplasty. Methods A systematic search is carried out through Medline (1966–2016.11), PubMed Embase (1980–2016.11), ScienceDirect (1985–2016.11) Cochrane Library. Only high quality studies are identified. Meta-analysis conducted with use Stata 11.0 software. Results One RCT five retrospective studies, published between 2010 2016, included in present meta-analysis. The indicates that there significant differences rate (RD = −0.02, 95% CI: −0.02 to −0.01, P  Conclusion Preoperative appears reduce risk infection, incidence revision surgery, length stay for No adverse effects, such as DVT or PE, appear be related preparation. Due limited evidence currently available, RCTs better study designs, larger sample sizes longer follow-ups needed.