Perinatal Risk Factors for Hay Fever — A Study Among 2550 Finnish Twin Families

摘要: Previous studies have suggested that perinatal factors influence the risk for asthma but population on and hay fever are few. We studied effect of among adolescent twins by a questionnaire study involving five consecutive nation-wide birth cohorts 16-year-old their parents. The parent-reported, doctor-diagnosed in adolescents associated with several characteristics was assessed logistic regression analysis individuals discordant pair analysis. In univariate factors, increased increasing weight (p trend = 0.048, OR those > or 3000 g 1.35, 95% CI 0.91-2.02 compared to < 2000 g) gestational age 0.04, born after 40 weeks gestation 2.24, 1.03-4.86, before 33 gestation) lower subjects hospitalised neonatal period (OR 0.74, 0.58-0.93). Because significant interactions between parental status (ponderal index, p 0.03 maternal 0.04), stratified were performed. positive association most obvious no history 0.03). Similar, though not significant, trends found other these families, whereas such fever, suggesting maturity increases absence genetic predisposition. However, only hospitalisation 0.75, 0.59-0.96) remained factor development when adjusted non-perinatal factors.