A Controlled Trial of Amantadine and Rimantadine in the Prophylaxis of Influenza a Infection

摘要: Abstract Four hundred fifty volunteers participated in a placebo-controlled, double-blind, randomized trial of the prophylactic effects rimantadine and amantadine during an outbreak influenza A. The subjects received drugs orally at dose 100 mg twice day for six weeks. Influenza-like illness occurred 41 per cent receiving placebo but only 14 those 9 (P<0.001 either drug vs. placebo). Laboratory-documented 21 recipients, 3 2 recipients (P<0.001). These findings represent efficacy rates 85 91 amantadine, as compared with placebo. More (13 cent) than (6 cent; P<0.05) or (4 P<0.01) withdrew from study because Central-nervous-system side effects. On basis this...