The Oral Microbiota May Have Influence on Oral Cancer.

摘要: The oral microbiota plays an important role in the human microbiome and health, imbalances between microbes their hosts can lead to systemic diseases chronic inflammation, which is usually caused by bacteria contributes cancer. There may be a relationship squamous cell carcinoma (OSCC); however, this has not been thoroughly characterized. Therefore, study, we compared compositions tumor sites opposite normal tissues buccal mucosal of 50 patients with OSCC using 16S rDNA sequencing. Richness diversity were significantly higher than control tissues. Cancer enriched six families (Prevotellaceae, Fusobacteriaceae, Flavobacteriaceae, Lachnospiraceae, Peptostreptococcaceae, Campylobacteraceae) 13 genera, including Fusobacterium, Alloprevotella Porphyromonas. At species level, abundances Fusobacterium nucleatum, Prevotella intermedia, Aggregatibacter segnis, Capnocytophaga leadbetteri, Peptostreptococcus stomatis, another five increased, suggesting potential association these OSCC. Furthermore, functional prediction revealed that genes involved bacterial chemotaxis, flagellar assembly lipopolysaccharide (LPS) biosynthesis are associated various pathological processes, increased group. Overall, profiles showed significant difference cancer tissue patients, might onsidered diagnostic markers treatment targets. Our study registered Chinese clinical trial registry (ChiCTR1900025253, http://www.chictr.org.cn/index.aspx).