Long-term treatment of established osteoporosis with intranasal calcitonin.

摘要: We examined the long-term effects of intranasal administration salmon calcitonin on bone and calcium metabolism in women with established osteoporosis (forearm fracture). Over a period 5 years, 14 received discontinuous (200 IU) plus (500 mg) daily for 3 years or 4 years. To allow assessment optimum duration therapy, patients whom treatment had been shorter intervals were also included. At end first 2 group receiving placebo lost significantly more from their spines forearms than year (P<0.01). In who completed further calcitonin, mineral contents increased continually. Bone loss forearm was arrested 1 year. Treatment lasting about prevented both areas. resulted net gains spinal but no benefits relation to forearms. Biochemical parameters turnover (serum alkaline phosphatase levels, plasma Gla protein fasting urinary hydroxy-proline/creatinine levels) exhibited similar declines irrespective treatment. It is concluded that longterm produced response achieved using therapy. The ratio between periods without 1∶2 2∶3.