Cellular communication and coupling within the suprachiasmatic nucleus.

摘要: In mammals, the part of nervous system responsible for most circadian behavior can be localized to a pair structures in hypothalamus known as suprachiasmatic nucleus (SCN). Importantly, when SCN neurons are removed from organism and maintained brain slice preparation, they continue generate 24h rhythms electrical activity, secretion, gene expression. Previous studies suggest that basic mechanism generation these is intrinsic individual cells SCN. If we assume competent oscillators, it obviously important understand how communicate remain synchronized with each other. Cell-to-cell communication clearly necessary conveying inputs outputs may involved ensuring high precision observed rhythm. addition, there growing body evidence number systems-level phenomena could dependent on cellular between pacemaker neurons. It not yet this synchronization occurs, but likely more than one already proposed mechanisms utilized. The purpose review summarize briefly possible by which oscillatory