Interleukin 1 regulates hematopoietic activity, a role previously ascribed to hemopoietin 1.

摘要: A murine in vitro assay was developed to measure potentiation of a proliferative response suboptimal concentrations the hematopoietic regulatory molecule granulocyte/macrophage colony-stimulating factor by an immature bone marrow population. The assay, designated 5-fluorouracil proliferation used characterize potentiating activity serum-free culture supernatants human tumor cell line HBT 5637. Molecular and biochemical analyses indicated that 5637-derived could be attributed interleukin 1 alpha. Serologic analysis using monoclonal antibody against purified recombinant alpha proved conclusively 5637 is due From these data, seems same synergistic formerly ascribed hemopoietin 1.