Monocyte function in patients with chronic granulomatous disease of childhood.

摘要: Adults with chronic granulomatous disease of childhood (CGD) have been described who remain relatively free infection despite markedly abnormal neutrophil function. Monocyte function in four adults this mild or atypical CGD syndrome was examined and compared to that normal controls two patients the more severe classic syndrome. Monocytes from killed 75.7% +/- 2.6% (mean SEM) ingested organisms at 30 min, while monocytes only 50.3% 4.2% bacteria (p less than 0.001). The difference bactericidal activity between small (75.7% versus 88.1% 3.7%, respectively) but statistically significant = 0.007). both showed impaired oxidative metabolism. Differences monocyte may explain why fewer infections patients. presence nonoxidative mechanisms is suggested by demonstration metabolic defects.