Cyclic adenosine monophosphate-phosphodiesterase (cAMP-PDE) in lymphocytes from patients with stage III and IV squamous cell carcinoma of the head and neck.
作者： Robert L. Banner , William K. Vaughn , King A. Hagey , W. Joseph Thompson , Evan M. Hersh
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摘要: In vivo skin tests using multiple recall and primary antigens such as dinitrochlorobenzine (DNCB) have established that there is decreased cellular-mediated immune response in patients with squamous cell carcinomas of the head neck. vitro testing lymphocytes blastogenic mitogens a measure lymphocyte function has not always shown statistical difference between controls. cAMP-PDE was assayed from normal controls - benign conditions various age groups. No significant found specific activity (Vmax) or affinity (Km) these The mean average used control value. untreated Stage III IV neck, Vmax Km were higher than This statistically significant. Postoperative values also determined but different. There no differences blastogenesis two
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sci-hub.se 参考文章(42)
W J Thompson, C P Ross, W J Pledger, S J Strada, R L Banner, E M Hersh, Cyclic adenosine 3':5'-monophosphate phosphodiesterase. Distinct forms in human lymphocytes and monocytes. Journal of Biological Chemistry. ,vol. 251, pp. 4922- 4929 ,(1976) , 10.1016/S0021-9258(17)33203-9
Earl W. Sutherland, T.W. Rall, Tara Menon, Adenyl Cyclase I. DISTRIBUTION, PREPARATION, AND PROPERTIES Journal of Biological Chemistry. ,vol. 237, pp. 1220- 1227 ,(1962) , 10.1016/S0021-9258(18)60312-6
W. Joseph Thompson, M. Michael Appleman, Characterization of Cyclic Nucleotide Phosphodiesterases of Rat Tissues Journal of Biological Chemistry. ,vol. 246, pp. 3145- 3150 ,(1971) , 10.1016/S0021-9258(18)62207-0
Tom R. Russell, Ira H. Pastan, Cyclic Adenosine 3':5'-Monophosphate and Cyclic Guanosine 3':5'-Monophosphate Phosphodiesterase Activities Are under Separate Genetic Control Journal of Biological Chemistry. ,vol. 249, pp. 7764- 7769 ,(1974) , 10.1016/S0021-9258(19)42033-4
R.W. Butcher, Earl W. Sutherland, Adenosine 3',5'-phosphate in biological materials. I. Purification and properties of cyclic 3',5'-nucleotide phosphodiesterase and use of this enzyme to characterize adenosine 3',5'-phosphate in human urine. Journal of Biological Chemistry. ,vol. 237, pp. 1244- 1250 ,(1962) , 10.1016/S0021-9258(18)60316-3
Jane Chalmer, P. G. Holt, D. Keast, Cell-mediated immune responses to transplanted tumors in mice chronically exposed to cigarette smoke. Journal of the National Cancer Institute. ,vol. 55, pp. 1129- 1134 ,(1975) , 10.1093/JNCI/55.5.1129
Carol A. Kauffman, John P. Phair, Calvin C. Linnemann, Gilbert M. Schiff, Cell-Mediated Immunity in Humans During Viral Infection I. Effect of Rubella on Dermal Hypersensitivity, Phytohemagglutinin Response, and T Lymphocyte Numbers Infection and Immunity. ,vol. 10, pp. 212- 215 ,(1974) , 10.1128/IAI.10.1.212-215.1974
David M.C. Ju, A study of the behavior of cancer of the head and neck during its late and terminal phases The American Journal of Surgery. ,vol. 108, pp. 552- 557 ,(1964) , 10.1016/0002-9610(64)90154-0
Tin Han, Hiroshi Takita, Immunologic impairment in bronchogenic carcinoma: a study of lymphocyte response to phytohemagglutinin. Cancer. ,vol. 30, pp. 616- 620 ,(1972) , 10.1002/1097-0142(197209)30:3<616::AID-CNCR2820300304>3.0.CO;2-Q
D. L. Palmer, W. P. Reed, Delayed Hypersensitivity Skin Testing. I. Response Rates in a Hospitalized Population The Journal of Infectious Diseases. ,vol. 130, pp. 132- 137 ,(1974) , 10.1093/INFDIS/130.2.132