The effect of age, sex, and lifestyle factors on micronucleus frequency in peripheral blood lymphocytes of the Bosnian population.
作者： Hilada Nefic , Inda Handzic
DOI: 10.1016/J.MRGENTOX.2013.03.001
关键词:
摘要: Abstract This study confirmed that the frequency of human lymphocyte biomarkers measured with cytokinesis-block micronucleus cytome (CBMNcyt) assay, is associated age, sex, and lifestyle factors. Cytogenetic analysis was carried out on samples from 100 healthy individuals living in Bosnia Herzegovina. Cells were cytologically scored for viability status, defined by proportion necrotic apoptotic cells; mitotic corresponding to ratios mono-, bi- multinucleated nuclear division index chromosomal damage, determined presence micronuclei, nucleoplasmic bridges or buds bi-nucleated cells. Ageing positively cytogenetic biomarkers. The females significantly higher than males. family history cancer. Furthermore, it correlated smoking: male subjects a smoking habit female smokers. However, alcohol observed decrease cells lymphocytes. micronuclei exposure medication. Lastly, negatively radiation.
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sci-hub.se 参考文章(68)
Michael Fenech, Stefano Bonassi, Julie Turner, Cecilia Lando, Marcello Ceppi, Wushou Peter Chang, Nina Holland, Micheline Kirsch-Volders, Errol Zeiger, Maria Paola Bigatti, Claudia Bolognesi, Jia Cao, Giuseppe De Luca, Marina Di Giorgio, Lynnette R. Ferguson, Aleksandra Fucic, Omar Garcia Lima, Valeria V. Hadjidekova, Patrizia Hrelia, Alicja Jaworska, Gordana Joksic, A.P. Krishnaja, Tung-Kwang Lee, Antonietta Martelli, Michael J. McKay, Lucia Migliore, Ekaterina Mirkova, Wolfgang-Ulrich Müller, Youichi Odagiri, Thierry Orsiere, Maria Rosaria Scarfı̀, Maria J. Silva, Toshio Sofuni, Jordi Suralles, Giorgio Trenta, Irena Vorobtsova, Anne Vral, Andrea Zijno, Intra- and inter-laboratory variation in the scoring of micronuclei and nucleoplasmic bridges in binucleated human lymphocytes. Results of an international slide-scoring exercise by the HUMN project Mutation Research-genetic Toxicology and Environmental Mutagenesis. ,vol. 534, pp. 45- 64 ,(2003) , 10.1016/S1383-5718(02)00248-6
Ingrid Nordenson, Felix Mitelman, Staffan Skerfving, Lars Hagmar, Benkt Högstedt, Lisbeth Knudsen, Sverre Heim, Marja Sorsa, Anton Brøgger, Bo Lambert, Christina Reuterwall, Kaija Linnainmaa, Inger-Lise Hansteen, Sisko Salomaa, Cancer Risk in Humans Predicted by Increased Levels of Chromosomal Aberrations in Lymphocytes: Nordic Study Group on the Health Risk of Chromosome Damage Cancer Research. ,vol. 54, pp. 2919- 2922 ,(1994)
D. Bettega, P. Calzolari, L. Doneda, F. Belloni, L. Tallone, J. L. Redpath, Differential effectiveness of solar UVB subcomponents in causing cell death, oncogenic transformation and micronucleus induction in human hybrid cells. International Journal of Radiation Biology. ,vol. 79, pp. 211- 216 ,(2003) , 10.1080/0955300031000075345
H. Thierens, A. Vral, L. De Ridder, A cytogenetic study of radiological workers: effect of age, smoking and radiation burden on the micronucleus frequency Mutation Research\/environmental Mutagenesis and Related Subjects. ,vol. 360, pp. 75- 82 ,(1996) , 10.1016/0165-1161(95)00058-5
R. Tomanin, C. Ballarin, B. Nardini, G. Mastrangelo, F. Sarto, Influence of smoking habit on the frequency of micronuclei in human lymphocytes by the cytokinesis block method Mutagenesis. ,vol. 6, pp. 123- 126 ,(1991) , 10.1093/MUTAGE/6.2.123
Pavel Rossner, Paolo Boffetta, Marcello Ceppi, Stefano Bonassi, Zdenek Smerhovsky, Karel Landa, Dagmar Juzova, Radim J. Šrám, Chromosomal Aberrations in Lymphocytes of Healthy Subjects and Risk of Cancer Environmental Health Perspectives. ,vol. 113, pp. 517- 520 ,(2005) , 10.1289/EHP.6925
Hitoshi Ishikawa, Ying Tian, Toru Yamauchi, Influence of gender, age and lifestyle factors on micronuclei frequency in healthy Japanese populations. Journal of Occupational Health. ,vol. 45, pp. 179- 181 ,(2003) , 10.1539/JOH.45.179
A.D. da Cruz, A.G. McArthur, C.C. Silva, M.P. Curado, B.W. Glickman, Human micronucleus counts are correlated with age, smoking, and cesium-137 dose in the Goiânia (Brazil) radiological accident Mutation Research/Environmental Mutagenesis and Related Subjects. ,vol. 313, pp. 57- 68 ,(1994) , 10.1016/0165-1161(94)90033-7
Stefano Bonassi, Angelo Abbondandolo, Lamberto Camurri, Leda Dal Prá, Marcella De Ferrari, Francesca Degrassi, Alessandra Forni, Laura Lamberti, Cecilia Lando, Paola Padovani, Isabella Sbrana, Daniela Vecchio, Riccardo Puntoni, Are chromosome aberrations in circulating lymphocytes predictive of future cancer onset in humans? Preliminary results of an Italian cohort study Cancer Genetics and Cytogenetics. ,vol. 79, pp. 133- 135 ,(1995) , 10.1016/0165-4608(94)00131-T
Noriaki Shimizu, Nobuo Itoh, Hiroyasu Utiyama, Geoffrey M Wahl, None, Selective Entrapment of Extrachromosomally Amplified DNA by Nuclear Budding and Micronucleation during S Phase Journal of Cell Biology. ,vol. 140, pp. 1307- 1320 ,(1998) , 10.1083/JCB.140.6.1307