Directed Evolution Generates a Novel Oncolytic Virus for the Treatment of Colon Cancer
作者： Irene Kuhn , Paul Harden , Maxine Bauzon , Cecile Chartier , Julie Nye
DOI: 10.1371/JOURNAL.PONE.0002409
关键词:
摘要: Background Viral-mediated oncolysis is a novel cancer therapeutic approach with the potential to be more effective and less toxic than current therapies due agents selective growth amplification in tumor cells. To date, these have been highly safe patients but generally fallen short of their expected value as monotherapies. Consequently, new approaches generating potent oncolytic viruses are needed. address this need, we developed method that term “Directed Evolution” for creating viruses.
harvard.edu
paperity.org参考文章(61)
Peter J. Kretschmer, Fang Jin, Cecile Chartier, Terry W. Hermiston, Development of a transposon-based approach for identifying novel transgene insertion sites within the replicating adenovirus. Molecular Therapy. ,vol. 12, pp. 118- 127 ,(2005) , 10.1016/J.YMTHE.2005.03.019
Daniel Stone, Anne Furthmann, Volker Sandig, André Lieber, The complete nucleotide sequence, genome organization, and origin of human adenovirus type 11. Virology. ,vol. 309, pp. 152- 165 ,(2003) , 10.1016/S0042-6822(02)00085-5
Ya-Fang Mei, Kristina Lindman, Göran Wadell, TWO CLOSELY RELATED ADENOVIRUS GENOME TYPES WITH KIDNEY OR RESPIRATORY TRACT TROPISM DIFFER IN THEIR BINDING TO EPITHELIAL CELLS OF VARIOUS ORIGINS Virology. ,vol. 240, pp. 254- 266 ,(1998) , 10.1006/VIRO.1997.8904
Fang Jin, Peter J. Kretschmer, Terry W. Hermiston, Identification of novel insertion sites in the Ad5 genome That utilize the Ad splicing machinery for therapeutic gene expression Molecular Therapy. ,vol. 12, pp. 1052- 1063 ,(2005) , 10.1016/J.YMTHE.2005.07.696
Kelley A. Parato, Donna Senger, Peter A. J. Forsyth, John C. Bell, Recent progress in the battle between oncolytic viruses and tumours. Nature Reviews Cancer. ,vol. 5, pp. 965- 976 ,(2005) , 10.1038/NRC1750
Zong-Yi Li, Shaoheng Ni, Xiangling Yang, Nancy Kiviat, André Lieber, Xenograft Models for Liver Metastasis: Relationship between Tumor Morphology and Adenovirus Vector Transduction Molecular Therapy. ,vol. 9, pp. 650- 657 ,(2004) , 10.1016/J.YMTHE.2004.01.021
Wen Yan, Galila Kitzes, Farid Dormishian, Lynda Hawkins, Adam Sampson-Johannes, Josh Watanabe, Jenny Holt, Vivian Lee, Thomas Dubensky, Ali Fattaey, Terry Hermiston, Allan Balmain, Yuqiao Shen, Developing Novel Oncolytic Adenoviruses through Bioselection Journal of Virology. ,vol. 77, pp. 2640- 2650 ,(2003) , 10.1128/JVI.77.4.2640-2650.2003
Konstantin Doronin, Karoly Toth, Mohan Kuppuswamy, Peter Ward, Ann E. Tollefson, William S. M. Wold, Tumor-Specific, Replication-Competent Adenovirus Vectors Overexpressing the Adenovirus Death Protein Journal of Virology. ,vol. 74, pp. 6147- 6155 ,(2000) , 10.1128/JVI.74.13.6147-6155.2000
K E Boyd, P J Farnham, Myc versus USF: discrimination at the cad gene is determined by core promoter elements. Molecular and Cellular Biology. ,vol. 17, pp. 2529- 2537 ,(1997) , 10.1128/MCB.17.5.2529
Peter W. Roelvink, Alena Lizonova, Jennifer G. M. Lee, Yuan Li, Jeffrey M. Bergelson, Robert W. Finberg, Douglas E. Brough, Imre Kovesdi, Thomas J. Wickham, The Coxsackievirus-Adenovirus Receptor Protein Can Function as a Cellular Attachment Protein for Adenovirus Serotypes from Subgroups A, C, D, E, and F Journal of Virology. ,vol. 72, pp. 7909- 7915 ,(1998) , 10.1128/JVI.72.10.7909-7915.1998