Apathy and depression in Alzheimer's disease are associated with functional deficit and psychotropic prescription

摘要: Background Apathy and depression are the most common neuropsychiatric features in Alzheimer's disease (AD). The clinical functional specific correlates of these syndromes not well known independently from cognitive deficits other behavioral disturbances. Material methods Six hundred eighty-six patients diagnosed with possible or probable AD were included a prospective multicenter study (REAL-FR). They had an assessment their status. Neuropsychiatric symptoms assessed Inventory (NPI) caregiver's burden was measured Zarit's Burden Scale. Results A majority at any stage presented one several psychological disturbances. Apathy concerned 43% and, without depression, associated more pronounced global cognition, everyday life instrumental abilities, nutritional status higher level. A high level psychotropic prescription, especially antidepressant, observed apathy. In multivariate analysis taking into account variables AD, apathy only significant predictors prescription. Conclusion Some negative such as have relation therapeutic outcomes Further studies needed to establish if represents particularly severe phenotype AD. Copyright © 2007 John Wiley & Sons, Ltd.