Atherosclerosis and apoprotein E. An enigmatic relationship.

摘要: In this article, we consider the role of apoprotein E in lipoprotein metabolism and especially potentially atherogenic lipoproteins. Particular consideration has been given to three features involvement lipid cell interactions. Evidence implicating free cholesterol as a mediator biosynthesis cholesterol-loaded macrophages is presented. Experiments pointing ligand promoting interaction beta-very-low-density (beta-VLDL) with are summarized. Finally, describe influence fat fed rhesus monkeys baboons on generation hepatogenous (from isolated liver perfusates) VLDL enriched ester E. These hepatic VLDLs, none which exhibits beta-electrophoretic mobility, promote esterification proportion their content. The complex genesis reversal atherosclerosis briefly discussed.