Inhaled frusemide does not affect lung mucociliary clearance in healthy and asthmatic subjects

摘要: Inhaled frusemide has been shown to protect against the bronchoconstrictor effect of several inhaled agents in asthmatic subjects by mechanism(s) that are unclear. Since loop diuretics can modulate Cl- transport airway epithelium, may alter quality and/or quantity periciliary layer, which turn affect lung mucociliary transport. We investigated a single inhalation nebulized (40 mg) on clearance four healthy and seven stable, mild asthmatics using an objective radioaerosol technique. Frusemide or placebo was double-blind, randomized, cross-over manner half hour after 5 microns polystyrene particles labelled with 99mTc, used for assessing clearance. The pulmonary function initial distribution were similar between runs within each two study groups. areas under tracheobronchial retention curves over 6 h observation period both Our findings show frusemide, at dose known inhibit responses, does not