Molecular Interactions between Thiostrepton and the TipAS Protein from Streptomyces lividans
作者： Cullen L. Myers , Jesse Harris , Jacky C. K. Yeung , John F. Honek
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摘要: In Streptomyces lividans, the expression of several proteins is stimulated by thiopeptide antibiotic thiostrepton. Two these, TipAL and TipAS, autoregulate their after covalently binding to thiostrepton; this irreversibly sequesters desensitizes organism its effects. work, additional molecular recognition interactions involved in critical event were explored utilizing various thiostrepton analogues site-directed mutants TipAS protein. Dissociation constants for ranged from 0.19 12.95 μM, depending on analogue. The contributions specific structural elements molecule interaction have been discerned, an unusual covalent modification between a new residue mutant has detected.
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