The attributes of plakins in cancer and disease: perspectives on ovarian cancer progression, chemoresistance and recurrence.

摘要: The plakin family of cytoskeletal proteins play an important role in cancer progression yet are under-studied cancer, especially ovarian cancer. These large have primary roles the maintenance integrity but also associated with scaffolds intermediate filaments and hemidesmosomal adhesion complexes mediating signalling pathways that regulate cellular growth, migration, invasion differentiation as well stress response. Abnormalities plakins, closely related spectraplakins, result diseases skin, striated muscle nervous tissue. Their prevalence epithelial cells suggests plakins may a recurrence. In this review article, we explore particularly plectin, periplakin envoplakin disease-states cancers emphasis on We discuss potential regulating cell survival, drug resistance. highlight relationships between epithelial-mesenchymal transition (EMT) stem (CSCs) how interaction these processes affect progression, chemoresistance ultimately propose molecular changes expression leads to benign tumours carcinomas, floating aggregates (commonly known spheroids) ascites microenvironment, which contribute sustenance disease. review, attempts been made understand crucial relation recurrence Video Abstract.