Aryl and biaryl compounds having mch modulatory activity

作者: Huizhong Gu , Tao Guo , Rachael C. Hunter , Douglas Walsh Hobbs

DOI:

关键词:

摘要: In one embodiment, this invention provides a novel class of compounds as antagonists the MCH receptor, methods preparing such compounds, pharmaceutical compositions containing or more formulations comprising and treatment, prevention amelioration diseases associated with receptor. An illustrative inventive compound is shown here.

参考文章(16)
Siegel Howard M, Padgett Webster H, Holzhauer William T, Volumetric metering device for particulate solids ,(1968)
Xavier Emonds-Alt, Pierre Goulaouic, Vincenzo Proietto, Broeck Didier Van, Arylalkylamines, process for their preparation and pharmaceutical compositions containing them ,(1991)
Kathleen M. Rupprecht, Christopher F. Claiborne, Andrew Kotliar, William H. Parsons, Wayne J. Thompson, Frank Kayser, Jianming Bao, Nigel Liverton, David A. Claremon, Heterocyclic potassium channel inhibitors ,(1999)
Takahiro Fukuroda, Akio Kanatani, Douglas J. MacNeil, Ying-Duo Gao, Lihu Yang, Yasuyuki Ishii, Nancy R. Morin, Takehiro Fukami, Masaki Ihara, Spiro-indolines as y5 receptor antagonists ,(1999)
Paul L. Ornstein, Dennis M. Zimmerman, M. Brian Arnold, Thomas J. Bleisch, Buddy Cantrell, Richard Simon, Hamideh Zarrinmayeh, S. Richard Baker, Mary Gates, Joseph P. Tizzano, David Bleakman, Allan Mandelzys, Kieth R. Jarvie, Ken Ho, Michelle Deverill, Rajender K. Kamboj, Biarylpropylsulfonamides as novel, potent potentiators of 2-amino-3- (5-methyl-3-hydroxyisoxazol-4-yl)- propanoic acid (AMPA) receptors. Journal of Medicinal Chemistry. ,vol. 43, pp. 4354- 4358 ,(2000) , 10.1021/JM0002836
Michal Lebi, Victor J. Hruby, Ana M. de L. Castrucci, Mac E. Hadley, Melanin concentrating hormone analogues: Contraction of the cyclic structure. II. Antagonist activity Life Sciences. ,vol. 44, pp. 451- 457 ,(1989) , 10.1016/0024-3205(89)90460-8
Katja Schultz, Manfred Hesse, Total Synthesis of (+)-(8S,13R)-Cyclocelabenzine† Helvetica Chimica Acta. ,vol. 79, pp. 1295- 1304 ,(1996) , 10.1002/HLCA.19960790506
Julius J. Matasi, Deen Tulshian, Ana Bercovici, Ginny D. Ho, Robbie L. McLeod, John A. Hey, Lisa S. Silverman, Richard W. Chapman, Francis M. Cuss, High affinity ligands for nociceptin receptor orl-1 ,(1999)
Margaret A. Cascieri, Euan Macintyre, John G. Menke, Roy G. Smith, Douglas J. Macneil, Combination therapy for the treatment of diabetes and obesity ,(1997)