Exploiting Metal–Ligand Bifunctional Reactions in the Design of Iron Asymmetric Hydrogenation Catalysts

摘要: ConspectusThis is an Account of our development iron-based catalysts for the asymmetric transfer hydrogenation (ATH) and pressure (AH) ketones imines. These chemical processes provide enantiopure alcohols amines use in pharmaceutical, agrochemical, fragrance, other fine industries. Fundamental principles bifunctional reactivity obtained by studies ruthenium Noyori’s group own with tetradentate ligands tertiary phosphine secondary amine donor groups were applied to improve performance these first iron(II) catalysts. In particular correct positioning a H–Fe–NH unit iron hydride complex leads exceptional catalyst activity because low energy barrier dihydrogen polar bond substrate. addition ligand structure this NH along array aryl orients incoming substrate hydrogen-bonding, steric i...