Fearful Symmetry: Subversion of Asymmetric Division in Cancer Development and Progression
作者： Jeevisha Bajaj , Bryan Zimdahl , Tannishtha Reya
DOI: 10.1158/0008-5472.CAN-14-2750
关键词:
摘要: Asymmetricdivisionisanevolutionarilyconservedprocessthat generates daughter cells with different fates through the unequal partitioning of fate determinants. While asymmetric division is critically important in generating diversity during development, its dysregulation can also promote oncogenesis. In particular, signals that shift normal balance symmetric and lead to a differentiation arrest trigger cancer progression. Here, we discuss studies have provided increasing support for this idea. Beginning original work carried out Drosophila, trace more recent mammalian systems suggest subversion contribute significantly development progression both hematologic malignancies solid cancers.
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