Cryptococcus and cryptococcosis in Iran during 1969–2019: A systematic review and meta-analysis

摘要: Abstract Objective Limited data are available on the epidemiology and etiology of cryptococcal infections in Middle East. We aimed to conduct systematic review meta-analysis summarize epidemiological prevalence Cryptococcus species complexes trees their surroundings, bird guano secretions, animals, highlight reported episodes cryptococcosis Iran. Materials methods Twelve databases, including PubMed, Science Direct, Scopus, Proquest, Google Scholar, Embase, ISI Web Science, as well national from January 1969 October 2019 were searched. Furthermore, gray literature (e.g., thesis, congress abstracts) was evaluated using Iran Doc www.thesis.research.ac.ir . Search process accomplished English or Persian language articles following keywords: “Cryptococcus”, “Cryptococcosis”, “invasive fungal infection”, “Humans”, “Birds”, “Pigeon”, “Animals”, “Tree”, “Eucalyptus”, “Iran”, both alone combination. Results Overall 36 studies eligible regarding The total rates tree 4.7% (95% CI: 2.3–7.8), 20.4% 10.7–32.2). Cryptococcosis animal, human 1.7% 0.01–5.1), 2.8% 0.7v6.1), respectively. highest (14.6%), (89.4%) Khorasan, animals (8.9%) Chaharmahal Bakhtiari, (4.4%) Mazandaran provinces reported. Conclusions Given significant risk for susceptible humans, mainly HIV-infected patients, it seems quite necessary adopt concrete preventive strategies pinpoint environmental habitats this yeast.