Benzothiazole derivatives bearing amide moiety: potential cytotoxic and apoptosis-inducing agents against cervical cancer.

摘要: Cervical cancer is a major cause of morbidity and mortality in women worldwide. In recent years, benzothiazole analogues have attracted considerable attention anticancer research. Therefore, this study, the earlier reported amide series derivatives were investigated for their antiproliferative activity. The activity was evaluated using 3-(4, 5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay, flow cytometric analysis, apoptosis DNA fragmentation on two human cervical cell lines: SiHa C33-A. data from investigation indicated that show pronounced cytotoxicity HPV16-positive cells compared with HPV-negative C-33A cells. in-vitro compounds HEK-293 noncancer line to establish selectivity. Cells treated showed prominent morphological features as evidenced by shrinkage, membrane blebbing, apoptotic nuclei, fragmentation. accumulation sub-G1 S-phase cycle C33-A, respectively. addition, these exert beneficial effect inducing apoptosis, chemoprevention cells, further ascertained assay. studied potent cytotoxic properties against C33-A lines thus represent an excellent starting point optimization therapeutically effective drugs.