Myeloid cells in the tumor microenvironment: Role of adenosine.

摘要: Adenosine, deriving from ATP released by dying cancer cells and then degradated in the tumor environment CD39/CD73 enzyme axis, is linked to generation of an immunosuppressed niche favoring onset neoplasia. The effects adenosine are mediated four receptors, named A1, A2A, A2B A3 that widely expressed on several immune cell populations. A critical role this nucleoside emerging modulation myeloid subsets accumulation functions into microenvironment, providing new insights might be useful for development novel therapeutic approaches aimed undermine privileged sites where grow proliferate.