Apolipoprotein E, cholesterol metabolism, diabetes, and the convergence of risk factors for Alzheimer’s disease and cardiovascular disease.

摘要: High fat diets and sedentary lifestyles are becoming major concerns for Western countries. They have led to a growing incidence of obesity, dyslipidemia, high blood pressure, condition known as the insulin-resistance syndrome or metabolic syndrome. These health conditions well develop along with, be precursors atherosclerosis, cardiovascular disease, diabetes. Recent studies found that most these disorders can also linked an increased risk Alzheimer's disease (AD). To complicate matters, possession one more apolipoprotein E epsilon4 (APOE epsilon4) alleles further increases severity many conditions, including AD. ApoE has roles in cholesterol metabolism Abeta clearance, both which thought significant AD pathogenesis. The apparent inadequacies may explain subjects carrying APOE alleles. This review describes some physiological biochemical changes above cause, how they related A diversity topics is covered, metabolism, glucose regulation, diabetes, insulin, function, amyloid precursor protein particular their relevance It seen abnormal lipid, consistently indicated central pathophysiology, possibly pathogenesis As diagnosis mild cognitive impairment early reliable, evidence accumulating such coronary artery factors AD, appropriate will likely reduce risk, improve prognosis people already suffering from conditions.